Semaglutide vs Tirzepatide vs Retatrutide — which burns more fat?

Here’s a head-to-head comparison of semaglutide, tirzepatide, and retatrutide with respect to fat loss / body-weight reduction based on the best available clinical and trial evidence:

Some high-dose semaglutide data show ~20.7% weight loss, which approaches tirzepatide results.

🧠 What This Means for Fat Loss

🔥 Semaglutide

• Highly effective at reducing body weight and appetite.
• Works mainly by decreasing calorie intake.
• Less strong compared with tirzepatide/retatrutide on average. Aesthetics Advisor

Summary: Good fat loss overall, but generally less than tirzepatide or retatrutide.

💪 Tirzepatide

• Dual action (GLP-1 + GIP) often leads to more weight and fat loss than semaglutide.
• Meta-analyses consistently show tirzepatide outperforms semaglutide for percentage weight loss.

Summary: Stronger efficacy than semaglutide — a good middle ground.

🚀 Retatrutide

• Triple-agonist design includes glucagon receptor activation, which may raise energy expenditure in addition to appetite suppression.
• Early Phase 2/3 data show it may produce the greatest weight (fat) loss of the three.
• Still investigational—not FDA-approved yet.

Summary: Highest reported fat loss potential so far, but not yet approved for general medical use.

📊 Practical Takeaway

Here’s how they generally stack up in terms of fat reduction potential:

1. Retatrutide (most potential fat loss, best metabolic elevation — investigational)
2. Tirzepatide (strong fat loss, widely available)
3. Semaglutide (effective but typically lower fat loss compared to the others)

⚠️ Important Notes

• Weight loss % is a proxy for fat loss, but body composition (fat vs lean mass change) varies and isn’t always reported in the same way across studies. Drugs.com
• Retatrutide results are early and from clinical trials — final outcomes and safety profiles are still being evaluated. Seneca Biomedical
• All these medications should be used under medical supervision with lifestyle measures for optimal and safe outcomes.