What is RARB?

RARB stands for Retinoic Acid Receptor Beta, a nuclear receptor protein encoded by the RARB gene.

It belongs to the retinoic acid receptor (RAR) family, which regulates gene transcription in response to retinoic acid (a derivative of Vitamin A).

Function:

Controls cell growth, differentiation, and apoptosis.

Involved in developmental biology and cancer research (especially acute promyelocytic leukemia, solid tumors, and epithelial cancers).

🔹 What are RARB Antibodies?

Antibodies specifically raised against RARB protein (human, mouse, rat, etc.).

Available in monoclonal or polyclonal formats.

Can target different epitopes (N-terminal, C-terminal, or DNA-binding domain).

🔹 Applications of RARB Antibodies

Western Blot (WB)

Detect RARB protein expression in cell or tissue lysates.

Immunohistochemistry (IHC) / Immunofluorescence (IF)

Study localization of RARB in tissues (nucleus vs. cytoplasm).

Chromatin Immunoprecipitation (ChIP)

Identify DNA binding sites of RARB.

Flow Cytometry (FC)

Detect intracellular RARB expression in single cells.

ELISA / IP (Immunoprecipitation)

Quantify or pull down RARB for further analysis.

🔹 Research & Clinical Relevance

Cancer biology:

Altered RARB expression is linked to lung, breast, and prostate cancers.

Stem cell & developmental studies:

RARB regulates differentiation pathways.

Pharmacology:

Key in studying retinoids and differentiation-inducing drugs.

✅ In summary:

RARB antibodies are research tools to detect, quantify, and study retinoic acid receptor beta, widely used in cancer research, developmental biology, and drug mechanism studies.