A NEW APPROACH TO BIOLOGICS PRODUCTION

Reduce the risk of a low titer cell line

Expression can vary significantly between different molecules using the same vector. Asimov’s CHO Edge System incorporates a GS knock-out CHO host, a hyperactive transposase, a library of >2500 characterized genetic elements and advanced computational tools, enabling exploration of vector design space.

System performance

Exploring vector design space

Selection stringency, heavy-chain/light-chain ratio, signal peptide pairings, and codon optimization all uniquely influence the expression of different molecules. Figure: Stable pool titers for four different molecules from six vector designs; the optimal vector design is unique to the molecule.

High titers across modalities

Routinely achieve 6-10 g/L clones across biologic modalities using the CHO Edge System. Figure: Top 12 clones for four different molecules analyzed in a 14 day Ambr® 15 platform process.

Highly stable clones

Transposase-mediated integration drives >80% titer stability over 75 generations. Figure: Average relative titer of 5-7 clones per molecule across 4 different molecules.

CONTACT INFO

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